PUBLICATIONS
2024
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J. Trejo and G. Scita (2024) Scaling the Cellular Frontier: Mechanobiology, Tissue Dynamics and Function. Curr. Opin. Cell Biology Cell Signaling. Jan 11:86:102318. Doi: 10.1016/j.ceb.2023.102318
N. Cheng, J. M. Pimentel and J. Trejo (2024). Ubiquitin-driven G Protein-Coupled Receptor Inflammatory Signaling at the Endosome. Mini-review. Am J. Phys. Cell Phys, 326:C1605-1610, April 22, 2024, doi.org/10.1152/ajpcell.00161.2024
L. M. Bohn, J. C. Garrison and J. Trejo. Chapter 2 “Cellular Receptors and Drug Concentration-Response Relationships” (ed. S. Ingraham and L. Wecker) and Brody’s Human Pharmacology, 7th edition. Elsevier. Copyright 2024.
2023
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N. Cheng and J. Trejo (2023). An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses. J. Biol. Chem, Oct 20, 299(12) 105370 doi: 10.1016/j.jbc.2023.105370
C. A. Birch, H. Wedegaertner, L. B. Orduña-Castillo, M. L. Gonzalez Ramirez, H. Qin and J. Trejo (2023). Endothelial APC/PAR1 distinctly regulates cytokine-induced pro-inflammatory VCAM-1 expression. Front Mol. Biosci. Cell. Biochem. Aug 24;10:1211597. doi: 10.3389/fmolb.2023.1211597
H. Wedegaertner O. Bosompra, I. Kufareva and J. Trejo (2023). Divergent regulation of a-arrestin ARRDC3 function by ubiquitination. Mol. Biol. Cell., May 24;mbcE23020055. doi:10.1091/mbc.E23-02-0055
J. A. Lawrence, P.A. Calvo, D. Ojeda-Juarez, H. Khuu, K. Soldau, D. Pizzo, J. Wang, A. Malik, T. Shay, E. Sullivan, B. Aulston. S. M. Song, J.A. Callendar, H. Sanchez, M. Geschwind, S. Roy, R. A. Rissman, J. Trejo, N.Tanaka, C. Wu, X. Chen, G. Patrick and C. Sigurdson (2023). Diminished neuronal ESCRT-0 function exacerbates AMPA receptor derangement and accelerates prion-induced neurodegeneration. J. Neurosci. May 24;43(21):3970-3984.
M. Werner Washburne, J. Trejo, R. E. Zambrana, M. E. Zavala, A. Martinec, A. Riestra, T. Delgado, S. Edwards,T. Escobar, D. Jamison-McClung, M. Vasquez, I. Vera, M. Guerra, D. I. Marinez, E. Gonzalez, and R. L. Rodriguez (2023). Early Career Latinas in STEM: Challenges and Solutions. Cell 186, Nov 9, 2023 doi.org/10.1016/j.cell.2023.10.016
A.G. Marshall, Z. Vue, H.K. Beasley, K. Neikirk, D. Stephens, C. N. Wanjalla, S.A.Damo, J. Trejo, P. Rodriguez- Aliaga, C. A. Headley, H. Shuler, K. Liu, N. Smith, E. Garza-Lopez, T. Barongan, E. Scudese, E. Spencer, J. Heemstra, A.D. Vazquez, S.A. Murray and A.J Hinton (2023). Diversity, Equity and Inclusion in the Laboratory: Strategies to Enhance Inclusive Laboratory Culture. Mol. Cell. 83, Nov 2, 2023 doi.org/10.1016/j.molcel.2023.09.011
2022
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O. Molinar-Inglis, J. M. Wozniak, N.J. Grimsey, L. Orduña-Castillo, Y. Lin, N. Cheng, M. L. G. Ramirez, C. A. Birch, J. D. Lapek, D. J. Gonzalez and J. Trejo (2022). Phosphoproteomic analysis of thrombin- and p38 MAPK- regulated signaling networks in endothelial cells. J. Biol. Chem. Apr;298(4)101801, 1-17.
H. Wedegaertner, W.-A. Pan, C. Gonzalez, D. J. Gonzalez and J. Trejo (2022). The a-arrestin ARRDC3 is an emerging multifunctional adaptor protein in cancer. Antioxid. Redox Signal. May;36(13-15):1066-1079.
B. Andrade, H. C. Medina-Munoz, E.T. Montaño, J. N. Roa, R. G. Sánchez, J. Tat, S. Hurst, M. E. Mouchka, J. Trejo and M. L. G. Ramirez (2022). COVID-19 threatens faculty diversity: postdoctoral scholars call for action. Mol. Biol. Cell, Voices. Mar 1;33(3).
D. A. Nicholas, J. Trejo and C. M. Termini (2022). Building a laboratory and networks during the COVID-19 pandemic. Trends in Biochem. Sciences Sept;47(9):725-727.
2021
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O. Molinar-Inglis, C. A. Birch, D. A. Nicholas, L. Orduña-Castillo M. Cisneros-Aguire, A. Patwardhan, B. Chen, N.J. Grimsey, L. J. Coronel, H. Lin, P.K.G. Menzies, M. A. Lawson, H. H. Patel and J. Trejo (2021) aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete β-arrestin-2-mediated Sphk1-S1PR1-Akt signaling axis. Proc. Natl. Acad. Sci. USA. Vol. 118 No. 29 e2106623118.
Rada CC, Mejia-Pena H, Grimsey NJ, Cordova IC, Olson J, Wozniak JM, Gonzalez DJ, Nizet V, and J. Trejo (2021) Heat shock protein 27 activity is linked to endothelial barrier recovery after pro inflammatory GPCR-induced disruption. Sci. Signal. 14, eabc1044, 31 Aug.
Arakaki AKS, Pan WA, Wedegaertner H, Roca-Mercado I, Chinn L, Gujral TS and J. Trejo (2021) α-arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis. J. Cell Sci. 134 (8):jcs254888.
Patwardhan A, N Cheng and J. Trejo (2021) Post-Translational Modifications of G Protein-Coupled Receptors Control Cellular Signaling Dynamics in Space and Time. Pharm. Rev. Jan, 73:120-151
Birch CA, O Molinar-Inglis, and J. Trejo (2021). Subcellular hot spots of GPCR signaling promote vascular inflammation. Curr. Opin. in Endo. Metabo. Research. Feb;16:37-42.
Trejo, D. Wingard, V. Hazen, A. Bortnick, K. Van Hoesen, A. Byars-Winston, C. Pfund and V. Reznik. (2021). A System-wide Health Sciences Faculty Mentor Training Program Is Associated with Improved Mentoring Effectiveness and Institutional Climate. J. Clin. Trans. Sci. Dec 23;6(1);e18. doi.org/10.1017/cts.2021.883
2020
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Zhou X, Z Yanghao, O Molinar-Inglis, MR Kunkel, M Chen, T Sun, J Ziang, JYJ Shyy, J. Trejo, AC Newton, and J Zhang (2020) Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat. Communications Nov 30: 11(1): 6088
Nicholas DA, VS Knight, KJ Tonsfeldt, T Terasaka, O Molinar-Inglis, SBZ Stephens, J. Trejo, AS Kauffman, PL Mellon, and MA Lawson (2020) GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci. Reports Aug 3;10(1):13063.
Keyes, A. Ganesan, O. Molinar-Inglis, A. Hamidzadeh, J. Zhang, M. Ling, J.Trejo, A. Levchenko, and J. Zhang. Signaling Diversity Enabled by Rap-1-Regulated Plasma Membrane ERK with Distinct Temporal Dynamics. eLife 2020 May 26;9:e57410. doi: 10.7554/eLife.57410
Lin Y, Wozniak JM, Grimsey NJ, Girada S, Patwardhan A, Molinar-Inglis O, Smith TH, Lapek JD, Gonzalez DJ, Trejo J. (2020) Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):5039-5048. doi: 10.1073/pnas.1917295117
J. Trejo (2020) The burden of service for faculty of color to achieve diversity and inclusion: the minority tax. Mol. Biol. Cell, 31: 2752-2754.
2019
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Grimsey NJ, Lin Y, Narala R, Rada CC, Mejia-Pena H, Trejo J. (2019) G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells. J Biol Chem. 294 (15) : 5867-5878. doi: 10.1074/jbc.RA119.007495.
Dores MR, Trejo J. (2019) Endo-lysosomal sorting of G-protein-coupled receptors by ubiquitin: Diverse pathways for G-protein-coupled receptor destruction and beyond. Traffic 20 (2) : 101-109 doi:10.1111/tra.12619. Review
Wingard D, Trejo J, Gudea M, Goodman S and Reznik V (2019) Faculty Equity, Diversity, Culture and Climate Change in Academic Medicine: A Longitudinal Study. J. Nat. Med. Assoc., 11:(1): 46-53.
Ochoa SD, Dores MR, Allen JM, Tran T, Osman M, Vazquez-Castellanos NP, Trejo J and Zayas R (2019) A modular laboratory course using planarians to study genes involved in tissue regeneration. Biochem. and Mol. Biol. Education. Sep;47(5):547-559.
2018
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J. Grimsey, R. Narala, C. C. Rada, S. Mehta, B.S. Stephens, I. Kufareva, J. Lapek, D. J. Gonzalez, T.M. Handel, J. Zhang and J. Trejo (2018). A tyrosine switch on NEDD4-2 E3 ligase transmits GPCR inflammatory signaling. Cell Reports, 18:24(12):3312-3323
M.R. Dores and J. Trejo (2018). Endo-lysosomal sorting of G protein-coupled receptors by ubiquitin: Diverse pathways for GPCR destruction and beyond. Traffic, Oct 23. doi: 10.1111/tra.12619.
Arakaki AKS, Pan WA, Trejo J. GPCRs in Cancer: Protease-activated Receptors, Endocytic Adaptors and Signaling. Int J Mol Sci 2018, 19(7) 1886, 1-24
Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The Unfolded Protein Response Regulator ATF6 Promotes Mesodermal Differentiation. Sci Signal 2018 Feb 13; 11(517)
Arakaki AKS, Pan WA, Lin H, Trejo J. The α-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G-protein coupled receptor lysosomal sorting and signaling. J Biol Chem 2018 Mar 2;293(9):3350-3362
2017
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Smith TH, Li JG, Dores MR, Trejo J. Protease-activated Receptor-4 and Purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt Signaling via Endosomal Recruitment of β-arrestin. J Biol Chem. 2017 Aug 18;292(33):13867-13878
Hamilton JR, Trejo J. Challenges and Opportunities in Protease-Activated Receptor Drug Development. Annu Rev Pharmacol Toxicol 2017Jan 6l57:349-373
Trejo J. A Reflection on Faculty Diversity in the 21st Century. Mol Biol Cell 2017 Nov 1:28(22):2911-2914
2016
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Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J. Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-arrestins. J Biol Chem 2016 Aug 26;291(35):18453-64
Dores MR, Grimsey NJ, Mendez F, Trejo J. ALIX regulates the ubiquitin-independent lysosomal sorting of the purinergic P2Y1 receptor via a YPX3L motif. PLoS One 2016, 11(6):e0157587.
Grimsey NJ and Trejo J. Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin. Curr Opin Hematol 2016, 23(3):274-279.
Grimsey NJ, Coronel LJ, Cordova IC, and Trejo J. Recycling and endosomal sorting of protease-activated receptor-1 is distinctly regulated by Rab11A and Rab11B Proteins. J Biol Chem 2016, 291:2223-2236.