Our research is focused on cell signaling in the context of vascular inflammation and breast cancer. The goal of our research program is to gain a thorough and mechanistic understanding of processes that control cell signaling by subsets of G protein-coupled receptors (GPCRs). We use multiple approaches and systems to delineate signal regulatory mechanisms that control endogenous GPCR function in endothelial cells and invasive breast carcinoma and assess the impact on cellular behavior and translate key biological findings in vivo using mouse models.
Current areas of research:
- Understanding the regulation and function of ubiquitin-driven GPCR endosomal signaling in vascular inflammation and breast cancer
- Delineating the role and function of alpha-arrestin ARRDC3 tumor suppressor activity in invasive breast cancer
- Identifying novel GPCR signaling pathways that enable endothelial cytoprotection
- Defining the mechanisms that control PAR1 biased signaling in the vascular endothelium